Optogenetic Gene Therapies for Chronic Pain Management
Revolutionizing chronic pain management through optogenetic gene therapies—offering a promising alternative for pain treatment instead of opioids and spinal cord stimulators.
Revolutionizing chronic pain management through optogenetic gene therapies—offering a promising alternative for pain treatment instead of opioids and spinal cord stimulators.
The therapy works by transforming pain-blocking neurons in the spine into photoreceptors, similar to those in your eyes, enabling them to be activated with a simple LED light. In this process, light-sensitive proteins are delivered to these neurons using functionalized gold nanorods and low-power laser light, with a promoter ensuring they only activate in neurons that can effectively block pain. This innovation represents a significant improvement in chronic pain management through the application of optogenetics.
In contrast to traditional care methods like electrical stimulation, which impacts all neurons—both those that block pain and those that transmit it—Opsin’s therapy specifically targets only the pain-blocking neurons. This potentially transformative approach could serve as an alternative to electrical spinal cord stimulation, offering relief to millions enduring chronic pain who have limited or no access to other treatment options.
This cutting-edge technology will be instrumental in advancing the research and development of a non-viral gene delivery system for optogenetic neuromodulation of the spine, providing a groundbreaking solution for severe chronic pain management without relying on opioids.


Our therapies, including those focused on chronic pain management and optogenetics for innovative pain treatment, are currently in development and have not been approved by any regulatory agency. They are not available for human use. The information provided is for educational purposes only.
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